This library includes supportive, mixed, neutral, and contrary findings so readers can see the evidence in context. Clicking a study opens its PubMed record in a new tab.
2023
•
Systematic review
Supportive
Effects of Protein and Essential Amino Acid Supplementation in Lower-Limb Surgery
Hayagawa, et al. • Nutrients, 2023
What the research found:
Nutritional enrichment via oral protein and EAA supplementation around lower-limb surgery may improve selected recovery timelines and skeletal architecture compared with standard post-operative care.
Why it matters for LeanGevity:
Supports broad clinical rationale for targeted amino acid support during catabolic and recovery-sensitive conditions.
View peer-reviewed article →
2024
•
Meta-analysis
Supportive
Effects of Resistance Exercise and Essential Amino Acid Supplementation on Muscle Quality
Jiang, et al. • Journal of Strength and Conditioning Research, 2024
What the research found:
Integrated resistance exercise combined with EAA supplementation showed improved muscle density measurements, enhanced metabolic power, and greater myofibrillar responses compared with exercise alone.
Why it matters for LeanGevity:
Supports pairing EAA with resistance exercise for synergistic muscle maintenance and restoration paths.
View peer-reviewed article →
2023
•
Umbrella review
Supportive
Ergogenic Benefits of HMB Supplementation on Body Composition
Mesquita, et al. • Nutrients, 2023
What the research found:
Umbrella analysis indicated highly significant pooled improvements in muscle retention index, whole arm strength capability, and fat-to-muscle ratio markers under supplementation.
Why it matters for LeanGevity:
Reinforces HMB as a supportive inclusion for recovery and lean-mass oriented strategies.
View peer-reviewed article →
2023
•
Systematic review
Supportive
Effects of HMB Supplementation on Muscle Mass and Strength in Sarcopenia
Li, et al. • Geriatrics, 2023
What the research found:
Randomized comparisons suggest HMB may help preserve lean mass and support functional strength improvements during ageing-related decline patterns.
Why it matters for LeanGevity:
Matches product rationale when preventing age-related muscle decline and structural weakness trajectories.
View peer-reviewed article →
2023
•
Systematic review
Mixed findings
Effects of Exercise Combined With HMB in Sarcopenia
Tong, et al. • Journal of Cachexia, Sarcopenia and Muscle, 2023
What the research found:
Combined exercise plus HMB interventions showed benefit in select endpoints, while evidence remained inconsistent across every outcome and measurement structure.
Why it matters for LeanGevity:
Highlights the need for context when interpreting muscle support evidence and where synergy with exercise may offer added value.
View peer-reviewed article →
2023
•
Systematic review
Supportive
Effects of Protein and Essential Amino Acid Supplementation in Lower-Limb Surgery
Hayagawa, et al. • Nutrients, 2023
What the research found:
Nutritional enrichment via oral protein and EAA supplementation around lower-limb surgery may improve selected recovery timelines and skeletal architecture compared with standard post-operative care.
Why it matters for LeanGevity:
Supports broad clinical rationale for targeted amino acid support during catabolic and recovery-sensitive conditions.
View peer-reviewed article →
2024
•
Systematic review
Supportive (Strength)
Effects of Choline TMG (Betaine) Supplementation on Exercise Performance
Kocapallı, et al. • Journal of Nutritional Biochemistry, 2024
What the research found:
Focused TMG (Betaine) supplementation may meaningfully support repeated-power metrics, perceived preparedness, and selected body-composition outcomes in trained populations.
Why it matters for LeanGevity:
Indicates TMG may support high-output performance and muscle strength where physical output patterns matter.
View peer-reviewed article →
2025
•
Systematic review
Controversial
Effect of GLP-1 Receptor Agonists on Body Composition
Santos et al. • Obesity Reviews, 2025
What the research found:
GLP-1 receptor agonist therapies can support total weight loss and reductions in body fat, but some studies also report reductions in lean mass during treatment.
Why it matters for LeanGevity:
Highlights the importance of preserving lean tissue and supporting muscle-focused nutrition during medically supported weight-management protocols.
View peer-reviewed article →
2022
•
Systematic review
Not Supportive
TMG (Betaine) Supplementation Fails to Improve Body Composition
Antunes et al. • Clinical Reviews in Food Science, 2022
What the research found:
Across available trials, TMG (Betaine) supplementation did not consistently improve body composition outcomes, including body fat or lean-mass measurements.
Why it matters for LeanGevity:
Shows that evidence for TMG is mixed depending on the outcome being studied, so claims should remain aligned with the strength of the available research.
View peer-reviewed article →
